Rol del glicocálix en la Sepsis: Revisión de La literatura y enfoque traslacional
DOI:
https://doi.org/10.29018/issn.2588-1000vol3iss24.2019pp1-10Palabras clave:
Glicocálix, sepsis, endotelioResumen
El endotelio vascular está cubierto por glicocálix en su región apical; una estructura compleja de macromoléculas formada por proteoglicanos y glicosaminoglicanos. Alteraciones en la fisiología de esta estructura en la sepsis podrían explicar la permeabilidad endotelial, vasoplejía, el estado procoagulante y la inflamación persistente; que clínicamente se ven asociados a disfunción de los órganos y consecuentemente alta mortalidad. Por lo que productos de la degradación del glicocálix podrían usarse como biomarcadores para diagnóstico y pronóstico. Además de convertirse en objetivos farmacológicos o guías de reanimación temprana, por lo que el conocimiento de los mecanismos moleculares involucrados es de vital importancia
en la práctica clínica.
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